Published by
@ShahidNShah
@ShahidNShah
February 23, 2023
Online
The blood-brain barrier is a set of specialized and highly selective cellular barriers that protects the central nervous system (CNS). While necessary under normal physiology, the blood-brain barrier prevents entry of many neurotherapeutics into the brain and biologic therapies such as antibodies and gene therapies are essentially excluded from the CNS. SRI International has developed an unbiased screening platform to identify peptides that mediate delivery throughout the CNS without disruption of the blood-brain barrier or destruction of biological cargo. This approach, named DiaCyt (Dia: Through and Cyt: Cell), utilizes high diversity phage-displayed peptide libraries to peptides that transport cargos across a cellular barrier.
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