Lipid-Based Drug Delivery: Dosage Form Design from Preclinical to First-in-Human
January
10

Lipid-Based Drug Delivery: Dosage Form Design from Preclinical to First-in-Human

 January 10, 2023 

Online


A high proportion of new drug candidates never reach market due to poor solubility, which limits their potential for absorption. As such, the solubility and permeability of an active pharmaceutical ingredient (API) are the driving forces behind bioavailability. In order to avoid development challenges and delays, it is critical to fully explore these parameters when developing formulations to enhance and maximise oral bioavailability. Lipid-based drug delivery systems offer a way to effectively deliver poorly soluble or bioavailable drugs in both preclinical and human studies. The physicochemical characteristics of the API determine if lipid delivery is an appropriate approach for dosage form design.

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